Recommended starting design
D-optimal sampling schedule
Balances information across clearance and volume while respecting the current five-sample burden and minimum spacing constraint.
Clinical development / Optimal design
Illustrative preview
Decision snapshot
The few numbers needed to judge whether this design is ready to operationalize.
ReadinessPreviewRun engine to score
Total samples12024 subjects x 5
Study window24 h0 to 24 hours
Condition no.-Lower is more stable
Where the design learns
Expected concentration profile with recommended collection points.
Expected concentrationRecommended sample
Design rationale
How this schedule supports the study objective.
Ready to continue?
Generate a protocol-ready report or use the schedule in clinical trial simulation.
Protocol-ready sampling schedule
Nominal times and practical collection windows for the clinical protocol.
| Sample | Nominal time | Allowed window | Study purpose | Priority |
|---|
Robustness across assumptions
Test whether sampling times remain informative when CL and V differ from the base model.
Run the stress test to generate a consensus schedule across plausible parameter scenarios.
Sparse cohort plan
Distribute the information burden across cohorts.
Build a sparse cohort plan after reviewing the primary schedule.