Bayes Pharma.ai PBPK/PBBM Studio Checking service...

Web-Native PBPK/PBBM Regulatory-Readiness Platform

14-organ PBPK, oral absorption, population simulation, ODE regimen engine, PBBM intelligence, enzyme/transporter IVIVE, advanced DDI, physiology populations, special populations, validation, BE/IVIVC, and qualification dossiers.

Core PBPK14 organs

PopulationP05–P95

Workflows10 modules

RoutesIV / Oral

PositioningMIDD OS

Scientific note: This frontend exposes regulatory-readiness workflows. Use “qualification-ready engineering PBPK/PBBM” until drug-specific parameter provenance, external validation, audit trail, and scientist sign-off are complete.

Engineering-grade PBPK, not regulatory-qualified. Core PBPK uses an analytically-stabilized explicit-Euler integrator with an automatic convergence check (see result panel for solver status per run); Regimen ODE uses scipy's adaptive solver when available -- solver method differs by tab.

Core 14-Organ PBPK

Look up a real drug by name (live PubChem)

SMILES (optional — auto-fills logP from RDKit)

Dose mg

Duration h

Route

Bioavailability

logP

fu plasma

pKa

Ionization

Clearance L/h

Central Volume L

Fed State

Permeability Scale

Solubility mg/mL

Use Well-Stirred

Hepatic CLint

Renal CL optional

GFR L/h

Active Secretion L/h

Ready.

Core PBPK Results

Nearest Literature Analog

Ranks the current SMILES by structural similarity against real, Simcyp/GastroPlus-validated PBPK case-study compounds. A sanity-check benchmark, not a prediction.

Run to compare against characterized reference compounds.

Population PBPK

N subjects

Seed

Omega CL

Omega V

Ready.

Prediction Interval

ODE Regimen Engine

Route

Dose mg

Dosing Interval h

N Doses

Duration h

Infusion Duration h

ka h⁻¹

Clearance L/h

Central V L

Peripheral V L

Q L/h

Bioavailability

Use Michaelis-Menten

Vmax mg/h

Km mg/L

Output dt h

Ready.

Regimen Profile

Advanced PBBM Absorption

Dose mg

Solubility mg/mL

GI Fluid mL

Permeability cm/s

Particle Radius µm

pKa

Ionization

Fed State

Ready.

IVIVE Clearance

fu plasma

fu incubation

Liver Weight g

MPPGL

Pathways JSON

Ready.

Advanced CYP/Transporter DDI

Fraction metabolized JSON Pathway inhibition / TDI / induction JSON Transporters JSON

Ready.

DDI Results

Physiology Population

N subjects

Seed

Population

Age Min

Age Max

Ready.

Population Diagnostics

Special Population Comparison

Populations JSON array

Ready.

Special Population Curves

Validation Metrics

Observed times Observed concentrations Predicted times Predicted concentrations

Ready.

Observed vs Predicted

BE / IVIVC Module

Reference JSON Test JSON

Dissolution time

Dissolution fraction

Absorption fraction

Ready.

BE / IVIVC Results

Qualification Dossier

Drug Name

Model Version

Intended Use

Ready.

Readiness Checklist

Ready.

Model structure PBBM IVIVE DDI BE/IVIVC Validation Dossier