/* Bayes Pharma Research & Publications — premium editorial/evidence UI v4
   Visual-only redesign. Existing scientific content, filters, drawers and data contracts are preserved. */
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html[data-theme=dark]{
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/* Chrome */
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.rp-brand span{font-size:1.03rem;letter-spacing:-.03em}.rp-brand small{font-size:.52rem;letter-spacing:.14em;color:color-mix(in srgb,var(--rp-muted) 86%,transparent)}
.rp-links{gap:26px}.rp-links a{font-size:.75rem;padding:10px 0}.rp-nav-cta{padding:10px 15px!important;border-radius:13px;background:color-mix(in srgb,var(--rp-surface) 92%,transparent);box-shadow:0 7px 20px color-mix(in srgb,var(--rp-strong) 5%,transparent)}
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.rp-subnav-inner{height:52px;gap:8px;padding-block:6px}.rp-subnav a{padding:9px 13px;border-radius:10px;font-size:.67rem;transition:background .16s ease,color .16s ease}.rp-subnav a:after{display:none}.rp-subnav a.active{background:var(--rp-surface);box-shadow:inset 0 0 0 1px var(--rp-line),0 5px 16px color-mix(in srgb,var(--rp-strong) 4%,transparent);color:var(--rp-strong)}

/* Hero */
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.rp-kicker{font-size:.62rem;letter-spacing:.15em;padding:7px 10px;border:1px solid color-mix(in srgb,var(--rp-brand) 24%,var(--rp-line));border-radius:999px;background:color-mix(in srgb,var(--rp-soft) 62%,transparent)}
.rp-hero h1{font-size:var(--rp-display);line-height:.91;letter-spacing:-.075em;margin:24px 0 0;max-width:9.7ch}.rp-hero h1 span{display:block;background:linear-gradient(112deg,var(--rp-brand),color-mix(in srgb,var(--rp-brand) 70%,var(--rp-cyan)));-webkit-background-clip:text;background-clip:text;color:transparent}
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.rp-actions{margin-top:30px}.rp-btn{min-height:46px;padding:11px 17px;border-radius:13px;font-size:.73rem;box-shadow:none}.rp-btn.primary{background:linear-gradient(135deg,var(--rp-strong),color-mix(in srgb,var(--rp-strong) 86%,var(--rp-brand)));color:var(--rp-bg);box-shadow:0 10px 26px color-mix(in srgb,var(--rp-strong) 16%,transparent)}
.rp-hero-meta{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:10px;margin-top:34px;padding-top:0;border-top:0;max-width:660px}.rp-hero-meta span{display:flex;flex-direction:column;gap:4px;padding:14px 15px;border:1px solid var(--rp-line);border-radius:15px;background:color-mix(in srgb,var(--rp-surface) 80%,transparent);font-size:.58rem;line-height:1.35;box-shadow:0 7px 20px color-mix(in srgb,var(--rp-strong) 4%,transparent)}.rp-hero-meta b{font-size:1rem;font-family:Inter,ui-sans-serif,system-ui;color:var(--rp-brand);letter-spacing:-.03em}

/* Portfolio summary */
.rp-band{padding:0 0 76px}.rp-stats{display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:12px;border:0;padding:0}.rp-stat{min-height:90px;display:flex;flex-direction:column;align-items:flex-start;justify-content:center;gap:4px;padding:18px 20px;border:1px solid var(--rp-line);border-radius:18px;background:color-mix(in srgb,var(--rp-surface) 86%,transparent);box-shadow:0 7px 22px color-mix(in srgb,var(--rp-strong) 4%,transparent)}.rp-stat strong{font-size:1.65rem;line-height:1;color:var(--rp-brand);letter-spacing:-.05em}.rp-stat span{font-size:.68rem;color:var(--rp-muted);font-weight:750}.rp-data-note{margin-top:12px;font-size:.66rem;color:var(--rp-muted)}

/* Sections */
.rp-section{padding:104px 0}.rp-section.alt{background:linear-gradient(180deg,color-mix(in srgb,var(--rp-paper) 96%,transparent),color-mix(in srgb,var(--rp-paper) 78%,var(--rp-bg)))}
.rp-head{grid-template-columns:minmax(0,1.02fr) minmax(360px,.72fr);gap:72px;align-items:end;margin-bottom:46px}.rp-head h2{font-size:var(--rp-h2);line-height:.96;letter-spacing:-.065em;margin-top:15px;max-width:780px}.rp-head p{font-size:.96rem;line-height:1.76;max-width:560px}

/* Programme portfolio */
#programmes{position:relative}#programmes:before{content:"RESEARCH PORTFOLIO";position:absolute;right:max(36px,calc((100vw - 1380px)/2));top:70px;font:850 .54rem/1 ui-monospace,SFMono-Regular,Menlo,monospace;letter-spacing:.18em;color:color-mix(in srgb,var(--rp-muted) 32%,transparent);pointer-events:none}
.rp-filterbar{gap:8px;margin:0 0 24px;border:0;padding:6px;border:1px solid var(--rp-line);border-radius:16px;background:color-mix(in srgb,var(--rp-surface) 70%,transparent);width:max-content;max-width:100%;overflow:auto;scrollbar-width:none}.rp-filterbar::-webkit-scrollbar{display:none}.rp-filter{flex:0 0 auto;padding:9px 12px;border-radius:10px;font-size:.65rem;transition:background .16s ease,color .16s ease,box-shadow .16s ease}.rp-filter:after{display:none}.rp-filter.active{background:var(--rp-surface);box-shadow:0 5px 16px color-mix(in srgb,var(--rp-strong) 6%,transparent),inset 0 0 0 1px var(--rp-line);color:var(--rp-strong)}
.rp-programmes{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:16px}.rp-programme{position:relative;display:grid;grid-template-columns:48px minmax(0,1fr) auto;grid-template-areas:"index main action" "index copy copy";gap:18px 20px;align-items:start;min-height:0;padding:24px;border:1px solid var(--rp-line);border-radius:24px;background:linear-gradient(145deg,color-mix(in srgb,var(--rp-surface) 97%,transparent),color-mix(in srgb,var(--rp-surface-2) 80%,transparent));box-shadow:0 9px 30px color-mix(in srgb,var(--rp-strong) 4%,transparent);overflow:hidden;transition:transform .18s ease,border-color .18s ease,box-shadow .18s ease}.rp-programme:before{content:"";position:absolute;left:0;top:0;bottom:0;width:3px;background:linear-gradient(var(--rp-brand),transparent 72%);opacity:.7}.rp-programme:hover{transform:translateY(-3px);border-color:color-mix(in srgb,var(--rp-brand) 36%,var(--rp-line));box-shadow:0 18px 44px color-mix(in srgb,var(--rp-strong) 8%,transparent)}.rp-programme:last-child:nth-child(odd){grid-column:1/-1}.rp-programme-index{grid-area:index;width:40px;height:40px;display:grid;place-items:center;padding:0;border-radius:12px;background:var(--rp-soft);color:var(--rp-brand);font-size:.62rem}.rp-programme-main{grid-area:main}.rp-programme-action{grid-area:action;text-align:right}.rp-programme-copy{grid-area:copy;padding-top:2px}.rp-programme-title{font-size:clamp(1.5rem,2vw,2.15rem);line-height:1.02;letter-spacing:-.045em}.rp-programme-top{margin-bottom:11px}.rp-id{font-size:.58rem}.rp-status{padding:5px 8px;border-radius:8px;font-size:.54rem}.rp-target{margin-top:10px;font-size:.72rem}.rp-programme-copy p{font-size:.82rem;line-height:1.68;max-width:680px}.rp-programme-evidence{gap:7px;margin-top:15px}.rp-programme-evidence span{padding:6px 8px;border:1px solid var(--rp-line);border-radius:8px;background:color-mix(in srgb,var(--rp-surface) 66%,transparent);font-size:.52rem}.rp-programme-evidence span.on{border-color:color-mix(in srgb,var(--rp-brand) 24%,var(--rp-line));background:color-mix(in srgb,var(--rp-soft) 60%,transparent)}.rp-linkbtn{min-height:36px;padding:8px 10px;border:1px solid var(--rp-line);border-radius:10px;background:var(--rp-surface);font-size:.64rem;text-decoration:none}.rp-linkbtn:hover{border-color:var(--rp-brand);background:var(--rp-soft)}

/* Featured research */
.rp-section.dark{position:relative;background:linear-gradient(145deg,#06100c,#081812 58%,#07130f);overflow:hidden}.rp-section.dark:before{content:"";position:absolute;inset:0;background:radial-gradient(circle at 76% 20%,rgba(104,216,175,.12),transparent 28rem),linear-gradient(rgba(255,255,255,.015) 1px,transparent 1px),linear-gradient(90deg,rgba(255,255,255,.015) 1px,transparent 1px);background-size:auto,52px 52px,52px 52px;pointer-events:none}.rp-section.dark>.rp-shell{position:relative;z-index:1}.rp-feature{grid-template-columns:minmax(0,.86fr) minmax(0,1.14fr);gap:64px}.rp-feature-copy h3{font-size:clamp(2.8rem,4.7vw,4.8rem);line-height:.94}.rp-feature-copy blockquote{padding:24px 0;font-size:1rem}.rp-convergence{padding:24px;border:1px solid rgba(255,255,255,.12);border-radius:22px;background:rgba(255,255,255,.025);box-shadow:0 24px 60px rgba(0,0,0,.18)}.rp-conv-table{border-radius:14px;overflow:hidden}.rp-conv-row>span{min-height:50px}

/* Evidence maturity */
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/* Scientific library */
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/* Decisions / changes */
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/* Collaboration */
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/* Drawer */
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/* Footer */
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/* Tablet */
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@media(max-width:760px){
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@media(max-width:480px){.rp-stats{grid-template-columns:1fr}.rp-stat{min-height:72px}.rp-programme-evidence{display:grid;grid-template-columns:repeat(2,minmax(0,1fr))}.rp-programme-evidence span{text-align:center}.rp-kicker{font-size:.55rem}.rp-footer-grid{grid-template-columns:1fr!important}}
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